Table 2.
Signaling pathways related to the roles of ARID1A in tumor initiation and tumor suppression.
| Roles of ARID1A | Related pathways | Genetic background | Citations |
|---|---|---|---|
| Tumor initiation | PI3K/AKT pathway, Wnt pathway | Conditional inactivation of Arid1a concurrently with Apc and Pten in ovarian cancer mouse model | (28) |
| Wnt pathway | ARID1A is necessary to promote tumorigenesis driven by APC inactivation | (29) | |
| Tumor suppression | PI3K/AKT pathway | ARID1A inhibits PIK3CA and PDK1 transcription by directly binding to the promoters in GC | (50) |
| ARID1A depletion improves radioresistance of pancreatic cancer via activation of the PI3K/AKT pathway | (76) | ||
| Conditional knockout of Arid1a and Pten in mouse model drives tumorigenesis of MOSE | (77) | ||
| YAP/TAZ pathway | ARID1A-SWI/SNF complex acts as an inhibitor of YAP and TAZ2 | (78) | |
| Wnt pathway | Loss of ARID1A in adult hepatocytes activates the transcription of erythropoietin mediated by β-catenin | (33) | |
| IFN pathway | The interaction between ARID1A and EZH2 antagonizes EZH2-mediated IFN responsiveness | (79) | |
| IL-6/STAT3 pathway | Hepatocyte-specific Arid1a deletion could lead to mouse steatohepatitis and HCC development | (36) |