Table 3.
Other SWI/SNF members involved in tumorigenesis and progression.
| SWI/SNF subunits | Genes | Molecular weight (kDa) | Domains | Associated cancers (mutation frequency) |
|---|---|---|---|---|
| BRG1 | SMARCA4 | 184.5 | Bromo, ATPase, HAS, QLQ | Ovarian cancer (>10%), small cell cancer of the ovary (>90%), non-small-cell lung cancer (35%), medulloblastoma (5%–10%) |
| BAF250b | ARID1B | 236 | ARID | Clear cell ovarian (>10%), childhood neuroblastoma (7%), liver cancer (5%–10%) |
| BAF47 | SMARCB1 | 44 | SNF5 | Rhabdoid tumor (>98%), familial schwannomatosis (30%–45%), epithelioid sarcomas (>55%), small-cell hepatoblastomas (36%) |
| BAF180 | PBRM1 | 193 | Bromo, HMG | Epithelioid sarcoma (83%), renal cancer (~40%) |
| BRD7 | BRD7 | 74 | Bromo | Breast cancer |
| BAF200 | ARID2 | 197 | ARID, zinc finger | Liver cancer (5%–14%), melanoma (5%–15%) |
| BRM | SMARCA2 | 181 | Bromo, ATPase | Rhabdoid tumor (60%), gastric (15%), breast (15%), and lung (4.8%–10%) cancers |
| BAF155 | SMARCC1 | 123 | Chromo, SANT, BRCT | Prostate cancer (~30%) |