Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 4;15:720807. doi: 10.3389/fncel.2021.720807

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Beier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Potential unobserved glial infection using one-step RABV. AAV helpers expressing red fluorescent protein mark starter cells, which are then targeted by EnvA-pseudotyped RABV by cellular expression of TVA. Because RABV encodes GFP, this makes starter cells red + green = yellow. By trans-complementation, RABV can spread to direct input cells (green). According to our postulated model, RABV may also spread to nearby glial cells (black), but these infections are aborted and thus, glial cells don’t express GFP. This leaves the GFP label specifically in neurons that preferentially connect to starter neurons. The tripartite synapse is highlighted in blue.