Figure 3.

Representative microphotograph of eight serial sections of lung obtained from a deadly case of COVID-19, with mixed conditions, with hemorrhagic lesions, fibrosis, immune infiltration, fibrin webs, and significant lung damage. (A) Representative H&E-stained images of lung classified as mixed conditions due to the combination of phenotypes I and II. (A) Low magnification allows us to appreciate the degree of damage, hemorrhagic, fibrosis, intravascular coagulation webs trapping immune cells within the blood vessels. Bar: 5 mm. (B–D) Correspond to higher magnification to denote the intravascular and hemorrhagic parenchymal lesions. Bar 100 µm and 25 µm. (E–G) Correspond to intravascular areas. Bar 100 µm and 25 µm. (H–J) represent contained hemorrhagic lesions within the parenchyma. Due to these characteristics, we named this phenotype mixed conditions. As indicated in A, arrows of different colors indicate representative cell types, areas with coagulation, cell loss (CL), Fibrin webs (FW), and red blood cells with spikes (RBCs). n=4 different individuals with 15-20 serial sections.