Table 4.
Three SNP-SNP-SNP interactions of surfactant protein genes associated with RDS.
| Gene1 | SNP1 | Gene2 | SNP2 | Gene3 | SNP3 | Effect | Odd's ratio | 95% CI | P-value adjusted |
|---|---|---|---|---|---|---|---|---|---|
| *SFTPA2 | rs1059046 | SFTPA2 | rs1965707 | SFTPA2 | rs1965708 | d1d2d3 | 0.55 | 0.46–0.65 | 7.74E-08 |
| SFTPA2 | rs1965707 | SFTPA2 | rs1965708 | SFTPA1 | rs1136450 | d1d2d3 | 0.55 | 0.46–0.65 | 1.30E-07 |
| d1d3 | 1.92 | 1.47–2.51 | 0.001018 | ||||||
| SFTPA2 | rs1059046 | SFTPA2 | rs17886395 | SFTPA1 | rs1059047 | d1d2d3 | 0.57 | 0.47–0.69 | 3.54E-05 |
| d1d2d3 | 0.59 | 0.49–0.72 | 0.000159 | ||||||
| SFTPA2 | rs17886395 | SFTPA2 | rs1965707 | SFTPA1 | rs1136451 | d1d2d3 | 1.57 | 1.3–1.89 | 0.001033 |
| SFTPA2 | rs1059046 | SFTPA1 | rs1136451 | SFTPA1 | rs1059057 | d1d2d3 | 0.54 | 0.44–0.65 | 8.12E-07 |
| SFTPA2 | rs17886395 | SFTPA1 | rs1059047 | SFTPA1 | rs1059057 | a1d2d3 | 4.76 | 2.67–8.47 | 0.001024 |
| SFTPA2 | rs17886395 | SFTPA1 | rs1136450 | SFTPA1 | rs1059057 | d1d2d3 | 0.57 | 0.47–0.69 | 0.000401 |
| SFTPA2 | rs17886395 | SFTPA1 | rs1059047 | SFTPA1 | rs1136450 | d1d2d3 | 0.53 | 0.44–0.65 | 8.12E-07 |
| SFTPA2 | rs1059046 | SFTPA1 | rs1136450 | SFTPA1 | rs4253527 | d1d2d3 | 1.53 | 1.28–1.81 | 0.001018 |
| SFTPA2 | rs17886395 | SFTPA1 | rs1059047 | SFTPA1 | rs1136451 | d1d2d3 | 0.62 | 0.51–0.75 | 0.001235 |
| *SFTPA1 | rs1059047 | SFTPA1 | rs1136450 | SFTPA1 | rs1136451 | d1d2d3 | 0.53 | 0.43–0.64 | 2.82E-07 |
| *SFTPA1 | rs1136450 | SFTPA1 | rs1136451 | SFTPA1 | rs1059057 | d1d2d3 | 0.57 | 0.47–0.69 | 1.77E-05 |
| *SFTPA1 | rs1059047 | SFTPA1 | rs1136451 | SFTPA1 | rs1059057 | d1a2d3 | 4.09 | 2.39–7.00 | 0.0012 |
| SFTPA2 | rs1059046 | SFTPD | rs721917 | SFTPB | rs7316 | d1d2 | 0.53 | 0.41–0.67 | 0.000197 |
| d1d2a3 | 0.51 | 0.40–0.64 | 6.71E-05 | ||||||
| SFTPA1 | rs1136450 | SFTPA1 | rs4253527 | SFTPB | rs7316 | d1d2 | 2.01 | 1.56–2.60 | 6.71E-05 |
| d1d2a3 | 1.96 | 1.52–2.52 | 0.000196 | ||||||
| SFTPA2 | rs1965708 | SFTPD | rs721917 | SFTPB | rs1130866 | d2d3 | 0.52 | 0.40–0.67 | 0.000362 |
| SFTPA2 | rs1059046 | SFTPA1 | rs4253527 | SFTPD | rs721917 | d1d3 | 0.51 | 0.40–0.64 | 3.54E-05 |
| d1a2d3 | 0.49 | 0.39–0.62 | 1.40E-05 | ||||||
| SFTPA2 | rs1059046 | SFTPA1 | rs1136450 | SFTPD | rs721917 | d1d2d3 | 0.53 | 0.45–0.63 | 1.12E-08 |
| SFTPA2 | rs17886395 | SFTPA1 | rs1136451 | SFTPD | rs721917 | d1d2d3 | 0.61 | 0.49–0.73 | 0.000467 |
| SFTPA2 | rs1965708 | SFTPA1 | rs1136450 | SFTPD | rs2243639 | d1d2d3 | 1.62 | 1.34–1.95 | 0.000273 |
| SFTPA2 | rs1965708 | SFTPA1 | rs1059057 | SFTPB | rs2077079 | d1d2d3 | 1.64 | 1.33–2.01 | 0.001275 |
| SFTPA2 | rs1059046 | SFTPB | rs2077079 | SFTPB | rs1130866 | d1d2d3 | 0.67 | 0.57–0.79 | 0.001295 |
| *SFTPB | rs2077079 | SFTPB | rs3024798 | SFTPB | rs7316 | d1d2d3 | 0.63 | 0.52–0.76 | 0.001029 |
Interaction effect: a- additive, d-dominant, for example, dda-dominant × dominant × additive among the three SNPs. The intragenic interactions are marked with asterisks (*).
The interactions associated with risk are highlighted in yellow.
Numbers 1, 2 and 3 in the effect column represent SNP1, SNP2, and SNP3, respectively.
The d1 stands for dominant effect for SNP1, d2 stands for dominant effect for SNP2, and a3 stands for additive effect for SNP3.
P-value adjusted is for gestational age, sex, and corrected for multiple comparisons by FDR, P < 0.01.