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. 2021 Oct 4;11:728583. doi: 10.3389/fonc.2021.728583

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Copyright © 2021 Qin, Li, Xiao, Wang, Gong, Wang, Zhu, Zhang, Zhang, Cao, Han, Wang, Ma and Sha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of SMAD2 or SMAD3 can inhibit the expression of NGF and BDNF. (A, B) qPCR and Western blotting analysis of the expression of SMAD2, SMAD3, NGF, BDNF in PANC-1 cell line after treated with SMAD2-specific siRNAs; (C, D) qPCR and Western blotting analysis of the expression of SMAD3, SMAD2, NGF, BDNF in PANC-1 cell line after treated with SMAD3-specific siRNAs; (E) qPCR analysis of the expression of NGF, BDNF in PANC-1 cell line after treated with TGFβ-1 and SMAD2-specific siRNAs; (F) Western blotting analysis of the expression of SMAD2, NGF, BDNF in PANC-1 cell line after treated with TGFβ-1 and SMAD2-specific siRNAs; (G) qPCR analysis of the expression of NGF, BDNF in PANC-1 cell line after treated with TGFβ-1 and SMAD3-specific siRNAs; (H) Western blotting analysis of the expression of SMAD3, NGF, BDNF in PANC-1 cell line after treated with TGFβ-1 and SMAD3-specific siRNAs. *p < 0.05, **p < 0.01; ^# p < 0.05, ^## p < 0.01.