Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 4;11:728583. doi: 10.3389/fonc.2021.728583

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Qin, Li, Xiao, Wang, Gong, Wang, Zhu, Zhang, Zhang, Cao, Han, Wang, Ma and Sha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HNK suppresses perineural invasion by inhibiting SMAD2/3 signaling. (A, B) Wound healing assays of the control group, HNK group, TGF β1 group, and HNK+TGF β1 group, scale bar = 200 μm; (C–F) Migration assay and invasion assay of the control group, HNK group, TGF β1 group, and HNK+TGF β1 group, scale bar = 100 μm; (G, H) Western blotting analysis of the expression of NGF, N-cadherin, E-cadherin, and Vimentin. (I, J) Cancer cell-DRG coculture model of the control group, HNK group, TGF β1 group, and HNK+TGF β1 group, scale bar = 200 μm; **p < 0.01, ***p < 0.001, ****p < 0.0001.