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. 2021 Oct 4;11:728583. doi: 10.3389/fonc.2021.728583

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Copyright © 2021 Qin, Li, Xiao, Wang, Gong, Wang, Zhu, Zhang, Zhang, Cao, Han, Wang, Ma and Sha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HNK inhibits EMT and perineural invasion in vivo. (A) Photographs of tumors in the subcutaneous pancreatic cancer model. (B) Tumor volumes were measured every week. (C) Tumor weights after sacrificing mice in the subcutaneous pancreatic cancer model. (D) Western blotting analysis of the expression of E-cadherin, N-cadherin, NGF, BDNF, and the activity of p-SMAD2/3 in tumor tissues. (E) The sciatic nerve function index in the sciatic nerve invasion model. (F) Photographs of tumors in the sciatic nerve (red dot: the injection point; green dot: the forefront of tumor cells). (G) Migration distances of tumors along the sciatic nerve were measured (from the injection point to the forefront of tumor cells). *p < 0.05, **p < 0.01.