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. 2021 Oct 4;12:726960. doi: 10.3389/fimmu.2021.726960

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Copyright © 2021 Gil-Manso, Carbonell, López-Fernández, Miguens, Alonso, Buño, Muñoz, Ochando, Pion and Correa-Rocha

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific T-cell responses in vaccinated healthy subjects. (A) Mean±SEM T-cell responses measured by IFNγ release (pg/ml); (B) IL-2 release (pg/ml); (C) IL-4 release (pg/ml) and (D) IL-10 release (pg/ml) (D) after in vitro stimulation with spike-derived peptides pool (S) or mixed nucleocapsid and membrane peptides (NM) from volunteers vaccinated with BNT162 (n=21) or mRNA-1273 (n=19) after 3, 7 and 14 days of receiving the second dose of the vaccine. The dotted line in (C) indicates the lower detection limit of the method for this cytokine, showing that the low concentrations detected are reliable. The linear mixed model was adjusted to evaluate each immunological covariate’s evolution over time in each group. *Significant difference when p < 0.05.