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. 2021 Oct 4;12:745315. doi: 10.3389/fimmu.2021.745315

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Copyright © 2021 Eloiflin, Auray, Python, Rodrigues, Seveno, Urbach, El Koulali, Holzmuller, Totte, Libeau, Bataille and Summerfield

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of pathways and upstream regulators modified by PPRV infections at 72 hpi. Qiagen’s IPA software provided a Zscore that informs on the activation status of pathways (A) and upstream regulators (B). Positive zscores (upregulated) are represented by an orange gradient while negative zscores (downregulated) are represented by a blue gradient. Pathways and upstream regulators have been classified in categories related to antiviral cell responses (dark blue square), MAPK signalling (light blue square), lipid metabolism (yellow square), cell death, survival (violet square) and proliferation (green square).