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. 2021 Oct 4;12:745315. doi: 10.3389/fimmu.2021.745315

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Copyright © 2021 Eloiflin, Auray, Python, Rodrigues, Seveno, Urbach, El Koulali, Holzmuller, Totte, Libeau, Bataille and Summerfield

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the activation of biofunctions and BTMs during PPRV infections at 72 hpi. Activated (A) and inactivated (B) biofunctions were found during the analysis. Qiagen’s IPA software provided a zscore that determines the activation (zscore>2) and the inactivation (zscore<-2) status of biological functions. All inactivated functions represent virus infection and replication functions and therefore reflect the induction of antiviral activities in the cells. (C) Analysis of goat blood transcriptional modules (BTMs) during PPRV infections of PBMCs at 72 hpi. Goat BTMs were activated or inactivated during infections (significance level: FDR < 0.1). Positive normalised enrichment score (NES > 0) means activation of a set of genes while negative NES (NES < 0) means inactivation.