Figure 7.

Representation of the mechanisms involved in the infection of activated PBMCs by different virulence strains of PPRV. The first steps of PPRV infectioninclude the transport of the virus by antigen-presenting cells (represented by dendritic cells) from the site of infection to the lymph nodes. Once in the lymph nodes, these cells trigger the activation and proliferation of T cells. This activation is associated with the expression of the SLAM receptor, as observed upon stimulation byConA. The virus may exit the DCs and then encounter the activated cells. The common effects of PPRV strains upon infection of activated T cells are the activation of an antiviral response, the inhibition of cell proliferation and the induction of cell death and apoptosis. In the case of a highly virulent strain, these activated cells are further infected and the inflammatory response is greater. Created with BioRender.com.