Figure 6.

Testing of various plaque core components for induction of congophilic and spherical maltese-cross amyloid core deposits. Different known amyloid plaque co-components including P component, alpha₁-antichymotrypsin, ApoE, C1q, C3, perlecan (HSPG), laminin, fibronectin, and type IV collagen were tested for their ability to form congophilic spherical maltese-cross amyloid core deposits. Only perlecan (HSPG) were shown to induce congophilic spherical maltese-cross amyloid core deposits identical to those seen in the AD brain (Castillo and Snow, 2006).