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. 2021 Oct 4;12:727850. doi: 10.3389/fimmu.2021.727850

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Copyright © 2021 Amodio, Ruggiero, Sgrulletti, Pighi, Cotugno, Medri, Morrocchi, Colagrossi, Russo, Zaffina, Di Matteo, Cifaldi, Di Cesare, Rivalta, Pacillo, Santilli, Giancotta, Manno, Ciofi Degli Atti, Raponi, Rossi, Finocchi, Cancrini, Perno, Moschese and Palma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-SARS-CoV-2 immune response before (D0) and at 21 days (D21) after the 1° dose and at 7 days (D28) after the 2° dose of the BNT162b2 mRNA COVID-19 vaccine. Humoral response is represented in (A) anti-RBD Ab (Log₁₀ U/ml) and (B) anti-trimeric S titer (AU/ml). Cellular response is depicted in (C). Humoral response of five patients lacking any cellular response is reported in (D, E). Non-paired non-parametric Mann–Whitney test was used in (A, B); paired non-parametric Wilcoxon tests were used to assess differences between D0 and D28 in HC and IEI in (C). HC, healthy controls; IEI, inborn errors of immunity patients.