Table 2.
Spearman correlations between the circulating levels of sCD40 and sCD40L (arbitrary unit, SUMMIT cohort) and IMT in the CCA and the carotid bulb region assessed by vascular ultrasound (measured at study inclusion)
| IMT measurements | CD40 (n=1,438 at inclusion; n=798 at follow-up) |
CD40L (n=1,438 at inclusion; n=798 at follow-up) |
||||
|---|---|---|---|---|---|---|
| r | P | P, adjusted* | r | P | P, adjusted | |
| Right | ||||||
| Mean IMT in CCA | 0.139 | 2.7×10–7 | 1.1×10–6 | 0.053 | 0.048 | 0.256 |
| Max IMT in CCA | 0.122 | 0.000006 | 0.000018 | 0.012 | 0.65 | 0.903 |
| Mean IMT in bulb | 0.234 | 1.4×10–16 | 6.6×10–16 | 0.081 | 0.005 | 0.039 |
| Max IMT in bulb | 0.268 | <1×10–16 | <1×10–16 | 0.077 | 0.008 | 0.055 |
| Left | ||||||
| Mean IMT in CCA | 0.088 | 0.001 | 0.0020 | 0.042 | 0.12 | 0.472 |
| Max IMT in CCA | 0.073 | 0.007 | 0.0070 | 0.000 | 0.99 | 0.990 |
| Mean IMT in bulb | 0.203 | 9.1×10–13 | 4.5×10–12 | 0.017 | 0.54 | 0.903 |
| Max IMT in bulb | 0.240 | <1×10–16 | <1×10–16 | 0.038 | 0.19 | 0.570 |
sCD40, soluble CD40; sCD40L, soluble CD40 ligand; SUMMIT, The SUrrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools; IMT, intima-media thickness; CCA, common carotid artery.
*
P-value adjusted for multiple comparisons.