Table 4.
Spearman correlations of CD40 and CD40L (A.U., CPIP cohort) measured in plaque homogenate versus plaque elements
| Variable | CD40 (n=198) |
CD40L (n=198) |
||||
|---|---|---|---|---|---|---|
| r | P | P, adjusted* | r | P | P, adjusted | |
| Histology (area %) | ||||||
| Smooth muscle α-actin | –0.070 | 0.33 | 0.33 | –0.142 | 0.048 | 0.094 |
| Calcium (van Kossa) | –0.208 | 0.004 | 0.016 | –0.268 | 0.00017 | 0.00068 |
| Oil Red O | 0.199 | 0.005 | 0.016 | 0.043 | 0.55 | 0.55 |
| Vulnerability index† | 0.178 | 0.014 | 0.029 | 0.180 | 0.014 | 0.041 |
| Cytokines (pg/g) | ||||||
| CXCL1 | 0.228 | 0.002 | 0.012 | 0.268 | 0.002 | 0.008 |
| IL-6 | 0.305 | 0.00032 | 0.0022 | 0.235 | 0.001 | 0.007 |
| IL-12p70 | 0.211 | 0.004 | 0.020 | 0.230 | 0.002 | 0.008 |
| Tumor necrosis factor α | 0.391 | 3.4×10–8 | 3.1×10–7 | 0.290 | 6.9×10–5 | 0.0006 |
| CCL5 | 0.021 | 0.772 | 0.772 | 0.200 | 0.007 | 0.014 |
| CCL2 | 0.175 | 0.017 | 0.034 | 0.186 | 0.001 | 0.007 |
| CCL4 | 0.202 | 0.006 | 0.020 | 0.186 | 0.011 | 0.014 |
| PDGF-AA/AB/BB | 0.268 | 0.0002 | 0.0018 | 0.243 | 0.001 | 0.007 |
| Plaque components (mg/g) | ||||||
| oxLDL (μU/g) | 0.236 | 0.001 | 0.004 | 0.259 | 0.00041 | 0.0037 |
CD40L, CD40 ligand; A.U., arbitrary unit; CPIP, Carotid Plaque Imaging Project; CXCL1, C-X-C motif chemokine ligand 1; IL, interleukin; CCL, chemokine (C-C motif) ligand; PDGF, platelet-derived growth factor; oxLDL, oxidized low density lipoprotein.
*
P-value adjusted for multiple comparisons;
†
Calculated as (CD68++glycophorin A++Oil Red O+ area%) / (smooth muscle α-actin++collagen++von Kossa+area%).