TABLE 1.
Variables analysed as potential biomarkers for mortality
| Variable | ROC | Univariate logistic regression | |||
|---|---|---|---|---|---|
| AUC | p‐value | OR | OR IC 95 | p‐value | |
| Age* | 0.8019 | .0005 | 1.0793 | 1.029183–1.131854 | .0017 |
| Sex (male) | 0.6130 | .1942 | 2.526 | 0.764313–8.35033 | .1287 |
| AHT* | 0.7026 | .0199 | 5.5800 | 1.533836–20.359662 | .0091 |
| DM | 0.5786 | .3667 | 2.2222 | 0.619494–7.971464 | .2205 |
| CVD | 0.5604 | .4878 | 1.7949 | 0.51024–6.313824 | .3621 |
| CKD | 0.5974 | .2631 | 4.0000 | 0.910787–17.567221 | .0663 |
| OBESITY | 0.5552 | .5260 | 0.3462 | 0.040472–2.960613 | .3327 |
| COPD | 0.5883 | .3103 | 3.2667 | 0.776781–13.73761 | .1062 |
| Onco | 0.5006 | .9940 | 0.9808 | 0.100886–9.534592 | .9866 |
| ImmunoD | 0.5013 | .9881 | 0.9792 | 0.183563–5.22311 | .9803 |
| Temperature | 0.5812 | .3510 | 1.1719 | 0.627006–2.190483 | .6191 |
| Heart rate | 0.5396 | .6490 | 1.0084 | 0.976758–1.041001 | .6081 |
| Resp rate* | 0.7695 | .0020 | 1.1780 | 1.048269–1.323747 | .0059 |
| SpO2 * | 0.7318 | .0077 | 0.8853 | 0.797259–0.982972 | .0225 |
| FiO2 | 0.6506 | .0835 | 1.2276 | 1.036604–1.453895 | .0175 |
| SpO2/FiO2 * | 0.8214 | .0002 | 0.9802 | 0.968543–0.99202 | .0011 |
| Lactate* | 0.8364 | .0001 | 9.2471 | 2.633093–32.474967 | .0005 |
| Absolute leukocytes | 0.5513 | .5556 | 1.0000 | 0.999919–1.000092 | .8960 |
| ANC | 0.5987 | .2568 | 1.0002 | 0.999983–1.000375 | .0733 |
| ALC* | 0.8234 | .0002 | 0.9969 | 0.994924–0.99884 | .0018 |
| AMC | 0.6110 | .2020 | 0.9983 | 0.99464–1.001913 | .3514 |
| N/L ratio* | 0.7974 | .0006 | 1.0658 | 1.005046–1.13017 | .0333 |
| Platelets* | 0.7383 | .0062 | 0.9999 | 0.999985–0.999998 | .0095 |
| Ferritin | 0.7403 | .0058 | 1.0005 | 0.999808–1.001173 | .1588 |
| D‐Dimer* | 0.7435 | .0051 | 1.0004 | 1.000033–1.000805 | .0332 |
| Creatinine | 0.7221 | .0107 | 1.1703 | 0.793126–1.726702 | .4283 |
| AST | 0.5117 | .8932 | 1.0037 | 0.997514–1.009897 | .2423 |
| ALT | 0.5416 | .6330 | 0.9924 | 0.974032–1.011074 | .4218 |
| LDH | 0.6558 | .0734 | 1.0037 | 0.999925–1.007448 | .0548 |
| CRP | 0.6981 | .0229 | 1.0044 | 0.998406–1.010426 | .1506 |
| PCT | 0.7110 | .0153 | 1.0199 | 0.984334–1.05684 | .2761 |
| qSOFA* | 0.8253 | .0002 | 9.3700 | 2.7216–32.259104 | .0004 |
| sCD25* | 0.7708 | .0019 | 1.0005 | 1.000001–1.001091 | .0497 |
| sCD86* | 0.7250 | .0096 | 0.9893 | 0.980009–0.998608 | .0244 |
| sCD137 | 0.5266 | .7597 | 1.0011 | 0.988669–1.013693 | .8628 |
| sCTLA‐4 | 0.5818 | .3472 | 0.1124 | 0.822844–0.646805 | 1.0468 |
| Galectin‐9 | 0.6883 | .0305 | 1.0000 | 0.999998–1.000012 | .1552 |
| sLAG‐3 | 0.6052 | .2268 | 1.0001 | 0.999987–1.000254 | .0759 |
| sPD‐1 | 0.6110 | .2020 | 1.0211 | 0.99–1.052975 | .1824 |
| sPD‐L1 | 0.6920 | .0267 | 1.0129 | 0.999984–1.025989 | .0503 |
| sTim‐3* | 0.7620 | .0025 | 1.0001 | 1.000011–1.000101 | .0138 |
| CCL‐2 | 0.6792 | .0395 | 1.0033 | 1.000145–1.006449 | .0403 |
| CXCL10 | 0.6883 | .0305 | 1.0006 | 0.999967–1.001227 | .0633 |
| IFNg | 0.5571 | .5115 | 1.0010 | 0.998441–1.003467 | .4582 |
| IL‐1β | 0.5227 | .7940 | 1.0389 | 0.872492–1.236977 | .6685 |
| IL‐2 | 0.5922 | .2894 | 1.1051 | 0.962296–1.269112 | .1569 |
| IL‐4 | 0.5961 | .2695 | 0.9703 | 0.921224–1.022008 | .2551 |
| IL‐6 | 0.7169 | .0127 | 1.0022 | 0.999664–1.004802 | .0885 |
| IL‐8 | 0.6409 | .1055 | 1.0307 | 1.004042–1.05814 | .0237 |
| IL‐10 | 0.5338 | .6981 | 1.0058 | 0.9953–1.016485 | .2787 |
| IL‐12p70 | 0.5597 | .4925 | 0.9428 | 0.860632–1.032824 | .2056 |
| IL‐17A | 0.5701 | .4204 | 0.9293 | 0.801122–1.07795 | .3327 |
| TNFα | 0.567 | .442 | 1.00005 | 0.913573–1.094726 | .9903 |
The asterisk * labels those variables included in the Wald backward stepwise regression model. In bold are the areas under the ROC curve (AUC) > 0.5 and the p‐values < .05.
Abbreviations: AHT, arterial hypertension; DM, history of diabetes mellitus; CVD, history of cardiovascular disease; CKD, history of chronic kidney disease; COPD, history of chronic obstructive pulmonary disease; OncoD, history of oncologic disease; ImmunoD, history of immunologic disease; Resp rate, respiratory rate; SpO2, oxygen saturation; FiO2, fraction of inspired oxygen; SpO2/FiO2, peripheral blood oxygen saturation to fraction of inspired oxygen ratio; ANC, absolute neutrophil counts; ALC, absolute lymphocyte counts; AMC, absolute monocyte counts; N/L Ratio, neutrophil to lymphocyte ratio; AST, aspartate transaminase; ALT, alanine transaminase; LDH, lactate dehydrogenase; CRP, c‐reactive protein, PCT, procalcitonin; qSOFA, quick sequential organ failure assessment score.