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. 2021 Aug 11;76(11):2854–2862. doi: 10.1093/jac/dkab264

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© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Distribution of pfk13 mutations in the Amazon basin between 1983 and 2019. Pie charts represent pfk13 allele frequencies per country. The total number of analysed samples is shown with the percentage and the 95% CI (in brackets) when a mutation was identified. Results are shown in the map of the Annual Falciparum Incidence (AFI) in the Americas region in 2017 (Annual Country Reports to PAHO/CDENT/Malaria). For Brazil, results are regrouped by closely located states. Notably, most Colombian and Ecuadorian samples (mutant included) represented here were collected on the Pacific coast (99.8% and 93.7%, respectively) and not in the Amazon region of the country. Brazilian states: AC, Acre; AM, Amazonas; AP, Amapá; MT, Mato Grosso; PA, Pará; RO, Rondônia; and RR, Roraima. Countries: COL, Colombia; ECU, Ecuador; GUF, French Guiana; GUY, Guyana; PER, Peru; SUR, Suriname; and VEN, Venezuela.