Table 4.

Summary of main susceptibility findings from studies with SWI or T2*-weighted data in ALS.

Publication	ALS	Controls	Main finding
Acosta-Cabronero et al. 35	28	39	Increased susceptibility in the motor cortex, premotor areas, substantia nigra, globus pallidus, and red nucleus
Lee et al. 98	26	26	Increased susceptibility in the motor cortex and decreased susceptibility in subcortical regions
Weidman et al. 75	43	15	Increased motor cortex susceptibility
Contarino et al. 43	42	23	Significant susceptibility skewness and trend toward increased susceptibility in the prefrontal cortex
Conte et al. 99	48	28	Increased motor cortex susceptibility
Conte et al. 100	47	38	Increased susceptibility skewness in the precentral cortex, driven by upper motor neuron involvement
Borsodi et al. 78	24	33	Increased susceptibility in the left corticospinal tract in bulbar ALS
Welton et al. 54	21	63	Increased susceptibility/iron concentration in the motor cortex, as part of a composite score for disease classification

ALS, amyotrophic lateral sclerosis; SWI, susceptibility weighted imaging.