Statement 18: Double-dose proton pump inhibitor therapy may be effective in patients with gastroesophageal reflux disease who do not show an adequate response to standard-dose proton pump inhibitor therapy.      Level of evidence: moderate      Strength of recommendation: weak      Experts’ opinions: agree strongly (42.2%), agree with some reservations (53.3%), undecided (2.2%), disagree (2.2%), and disagree strongly (0.0%)