Table 1. GO functional enrichment analysis for the DEGs.
| Term | Category | P-value | UniProt ID |
|---|---|---|---|
| BP | |||
| Extracellular matrix organization | GO:0030198 | 2.66E-15 | COL1A1, COL3A1, COL14A1, LAMA4, COL6A2, COL5A3, COL5A2, COL6A1, COL6A3 |
| Collagen fibril organization | GO:0030199 | 3.10E-09 | COL1A1, COL3A1, COL14A1, COL5A3, COL5A2 |
| Cellular response to amino acid stimulus | GO:0071230 | 1.71E-06 | COL1A1, COL3A1, COL5A2, COL6A1 |
| Cell adhesion | GO:0007155 | 1.72E-06 | COL1A1, COL15A1, LAMA4, COL6A2, COL6A1, COL6A3 |
| Protein heterotrimerization | GO:0070208 | 2.32E-05 | COL1A1, COL6A2, COL6A1 |
| Skin development | GO:0043588 | 1.42E-04 | COL3A1, COL5A3, COL5A2 |
| Skeletal system development | GO:0001501 | 0.00229126 | COL1A1, COL3A1, COL5A2 |
| Blood vessel development | GO:0001568 | 0.020188218 | COL1A1, LAMA4 |
| Cell–matrix adhesion | GO:0007160 | 0.047226948 | COL3A1, COL5A3 |
| Osteoblast differentiation | GO:0001649 | 0.054392332 | COL1A1, COL6A1 |
| Platelet activation | GO:0030168 | 0.059988631 | COL1A1, COL3A1 |
| Regulation of immune response | GO:0050776 | 0.091476749 | COL1A1, COL3A1 |
| MF | |||
| Extracellular matrix structural constituent | GO:0005201 | 2.59E-13 | COL1A1, COL3A1, COL15A1, COL14A1, LAMA4, COL5A3, COL5A2 |
| Platelet-derived growth factor binding | GO:0048407 | 1.39E-05 | COL1A1, COL3A1, COL6A1 |
| SMAD binding | GO:0046332 | 0.022698305 | COL3A1, COL5A2 |
| Collagen binding | GO:0005518 | 0.03154496 | COL14A1, COL5A3 |
| CC | |||
| Endoplasmic reticulum lumen | GO:0005788 | 2.66E-15 | COL1A1, COL3A1, COL15A1, COL6A2, COL5A3, COL5A2, COL6A1, COL6A3 |
| Collagen trimer | GO:0005581 | 3.10E-09 | COL1A1, COL3A1, COL14A1, LAMA4, COL6A2, COL5A3, COL5A2, COL6A1, COL6A3 |
| Extracellular matrix | GO:0031012 | 1.71E-06 | COL1A1, COL3A1, COL14A1, COL5A3, COL5A2 |
| Extracellular region | GO:0005576 | 1.72E-06 | COL1A1, COL3A1, COL5A2, COL6A1 |
| Proteinaceous extracellular matrix | GO:0005578 | 2.32E-05 | COL1A1, COL15A1, LAMA4, COL6A2, COL6A1, COL6A3 |
| Extracellular space | GO:0005615 | 1.42E-04 | COL1A1, COL6A2, COL6A1 |
| Extracellular exosome | GO:0070062 | 0.00229126 | COL3A1, COL5A3, COL5A2 |
| Sarcolemma | GO:0042383 | 0.020188218 | COL1A1, COL3A1, COL5A2 |
| Collagen type V trimer | GO:0005588 | 0.047226948 | COL1A1, LAMA4 |
| Collagen type VI trimer | GO:0005589 | 2.98E-16 | COL3A1, COL5A3 |
Category refers to the GO functional categories.