Figure 6.
Therapeutic effects of intrathecal injection. Motor function was assessed using a balance beam test with 15-month-old MLD mice left untreated (closed bars, n = 6), treated with AAV9/ARSA at 1 year (gray bars, n = 5), 6 weeks of age (open bars, n = 4) or wild type (WT) (diagonally hatched bars, n = 8). (a) Latency: the time required to traverse each beam. (b) Slips: the number of times the hind feet of mice slipped off a beam. All animals were given three trials on the beams. *p < 0.03.