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. 2021 Oct 15;11:16866. doi: 10.1038/s41598-021-96351-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo distribution of lapatinib-loaded hiPSC-platelets. (A) Body weights of variously treated BBM1-derived tumor-bearing female NOD/SCID mice (n = 7) over a 30-day period. ** indicates p < 0.001. (B) Plasma concentrations of lapatinib, measured by LC–MS/MS after injection with free lapatinib or lapatinib-loaded hiPSC- and donor-derived platelets in NOD/SCID mice (n = 7). Lapatinib-loaded hiPSC- and donor-derived platelets vs. free lapatinib, * p < 0.001. (C) Lapatinib concentrations in various tissues of female NOD/SCID mice (n = 7), collected 4 h after infusion with free lapatinib or lapatinib-loaded hiPSC- and donor-derived platelets. * indicates p < 0.001.