Table 2. SAR Studies for Other Parts of Lead Compounds.

		biochemical inhibition IC50 (μM)a
compd	R	JNK3	JNK1 (R)b	JNK2 (R)b	p38α (R)b
18		0.002	0.258 (129)	0.029 (15)	0.024 (12)
19		0.005	1.24 (248)	ndc	0.065 (13)
20		0.03	2.42 (80)	1.02 (33)	0.286 (9)
21		0.024	4.73 (197)	0.414 (17)	0.481 (20)
3		0.005	0.69 (139)	ndc	0.086 (17)
22		0.002	0.26 (130)	0.074 (37)	0.057 (28)
4		0.006	0.94 (157)	0.256 (43)	0.26 (43)
23		0.002	0.213 (106)	0.052 (26)	0.106 (50)
24		0.012	0.872 (73)	0.14 (11)	0.38 (31)
25		>10	>10	ndc	>10
26	2-Cl-3-F	0.169	>10 (>59)	ndc	1.42 (8)
27	2-Cl-4-F	0.079	6.0 (76)	ndc	0.49 (51)
28	2-Cl-5-F	1.07	>10	ndc	2.89
29	2-Cl-6-F	0.005	0.387 (77)	0.074 (15)	0.106 (21)

^aThe average of ≥2 experiments with errors within 30% of the average.

^bR: ratio of IC₅₀ values for JNK1, JNK2, and p38α over JNK3.

^cNot determined.