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. 2021 Sep 21;12(10):1546–1552. doi: 10.1021/acsmedchemlett.1c00334

Table 4. Brain and Plasma Concentration of Inhibitor 29 in Micea.

compd plasma concentration (2 h) brain concentration (2 h)
29 (po, 30 mg/kg) 5.9 μM 3.3 μM
a

Data were generated from four determinations, and samples were collected 2 h after dosing. Formulation: 1.75% DMSO, 2% Tween80, 18% of the lipid mixes in PBS (pH 6.0). The lipid mixture: 3:1 mixture of CapMul MCM:Captex 355 was mixed with PEG35 at 15:85. Brain/plasma ratio: 56%.