Table 4. Brain and Plasma Concentration of Inhibitor 29 in Micea.
| compd | plasma concentration (2 h) | brain concentration (2 h) |
|---|---|---|
| 29 (po, 30 mg/kg) | 5.9 μM | 3.3 μM |
Data were generated from four determinations, and samples were collected 2 h after dosing. Formulation: 1.75% DMSO, 2% Tween80, 18% of the lipid mixes in PBS (pH 6.0). The lipid mixture: 3:1 mixture of CapMul MCM:Captex 355 was mixed with PEG35 at 15:85. Brain/plasma ratio: 56%.