Table 1.
New Small-Molecule Anticancer Drugs Approved by the FDA,2 1981-2010
| Product Classification | Number Approved | Examples |
|---|---|---|
| Natural | 11 | paclitaxel (1993), romidepsin (Istodax, Celgene; 2010) |
| Totally synthetic | 20 | soraienib (Nexavar, Bayer/Onyx; 2005), miriplatin (2010) |
| Derived from a natural product | 32 | temsirolimus (Torisel, Pfizer; 2007), vinflunine (2010), cabazitaxel (Jevtana, Sanofi-Aventis; 2010) |
| Synthesized, but pharmacophore is from a natural product | 11 | clofarabine (Clolar, Genzyme; 2005), decitabine (2006) |
| Synthesized, but mimics a natural product | 16 | dasatinib (Sprycel, Bristol-Myers Squibb; 2006), pazopanib (Votrient, Novartis; 2009) |
| Synthesized, but pharmacophore is from a natural product and mimics a natural product | 8 | vorinostat (Zolinza, Merck; 2006), degarelix (Firmagon, Ferring; 2009) |