Table 3.

Retinal microvasculature and cognition in previous studies

Study	Sample	Age (year)	Cognition	OCTA parameters	Correlation (r)
Present Study	20 cognitively normal older adults	71.0 ± 5.4	MoCA	RVD SVD DVD	RVD, rs = 0.37, P = 0.02 SVD, rs = 0.60, P < 0.001
Criscuolo et al. 201837	27 aMCI	73 ± 6	MMSE	SCP, DCP, RPC, FAZ	No association
Zabel et al. 201939	27 AD	74.1 ± 5.9	MMSE	DVD, SVD, FAZ	No correlation
Lahme et al. 201838	36 AD	68.0 ± 9.3	MMSE	FD	No correlation
Zhang et al. 201940	3 eAD 13 aMCI	73.0 ± 8.2	MoCA	SVD, peripapillary RPC VLD	SVD, r = 0.36, P = 0.043, PRC VLD, r = 0.46, P = 0.01
Bulut et al. 201836	26 ATD	74.2 ± 7.6	MMSE	VD FAZ	VD, r = 0.438, P = 0.001 FAZ, r = −0.531, P < 0.001
Wang et al. 202141	62 AD, 47 MCI, and 49 HC	74.2 ± 7.6	MMSE Fazekas score	VD	No correlation

MoCA: Montreal cognitive assessment; RVD: vessel density in the retinal vascular network; SVD: vessel density in the superficial vessel plexus; aMCI: Amnestic Mild Cognitive Impairment; MMSE: the Mini-Mental State Examination test; SCP: superficial capillary plexus; DCP: deep capillary plexus; RPC: radial peripapillary capillary; FAZ fovea avascular zone; AD: Alzheimer’s Disease; MCI: mild cognitive impairment; HC: healthy control; DVD: vessel density in deep retinal vascular plexus; FD: flow density; eAD: early Alzheimer’s Disease; RPC VLD: radial peripapillary capillary vessel length density; ATD: Alzheimer’s type dementia; VD: vessel density.