Table 2. Mouse PK Parameters for Compounds 2 and 31.

	compound
	2	31
Cmax (ng/mL)	41.0	791
C8h (ng/mL)b	6.73	297
AUC0–8h (h*ng/mL)b	100.6	4001c
clearance rate (L/h/kg)	7.23	1.83
Vd (L/kg)	32.2	9.35
T1/2 (h)	3.1	3.5c
FPO (%)a,b	2.4	24c

^aDoses: 3 mg/kg IV and 30 mg/kg PO.

^bMeasurements conducted up to 8 h.

^cValues for 31 exceed the 8 h time point and are underestimated.