Table 4.
Diagnostic Validity of Xpert MTB/RIF and Xpert MTB/RIF Ultra Assays on Stool Specimen Compared With Culture Results of Induced Sputum Specimen Among Children (< 15 Years of Age) With Presumptive Pulmonary Tuberculosis Enrolled From Selected 4 Tertiary Care Hospitals in Dhaka, Bangladesh, January 2018–April 2019 (N = 447)
| Investigation | Culture on Induced Sputum | Sensitivity, % (95% CI) | Specificity, % (95% CI) | |||
|---|---|---|---|---|---|---|
| Positive | Negative | |||||
| No. | (%)a | No. | (%)a | |||
| Total | 9 | (100.0) | 438 | (100.0) | … | … |
| Xpert MTB/RIF | ||||||
| Positive | 7 | (77.8) | 4 | (0.9) | 77.8 (45.3–93.7) | 99.1 (97.7–99.6) |
| Negative | 2 | (22.2) | 434 | (99.1) | … | … |
| Xpert MTB/RIF Ultrab | ||||||
| Positive | 8 | (88.9) | 52 | (11.9) | 88.9 (56.5–98.0) | 88.1 (84.7–90.8) |
| Negative | 1 | (11.1) | 385 | (88.1) | … | … |
| Xpert MTB/RIF Ultra (trace call as negative)b | ||||||
| Positive | 7 | (77.8) | 5 | (1.1) | 77.8 (45.3–93.7) | 98.9 (97.4–99.5) |
| Negative | 2 | (22.2) | 432 | (98.9) | … | … |
Abbreviation: CI, confidence interval.
aColumn percentage.
bOne stool specimen showed invalid result on Xpert Ultra assay.