Table 2.
Pooled and subgroup analyses of the association between the XRCC2 Arg188His polymorphism and colorectal cancer risk.
| Study n | His versus Arg | His/His versus Arg/Arg | Arg/His versus Arg/Arg | Dominant model | Recessive model | |
|---|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | ||
| Total | 7 | 1.14 (1.01, 1.29) | 1.34 (0.95, 1.89) | 1.19 (0.92, 1.54) | 1.15 (0.99, 1.32) | 1.22 (0.87, 1.71) |
| Ethnicity | ||||||
| Asian | 3 | 1.19 (0.73, 1.93) | 1.53 (0.81, 2.88) | 1.30 (0.58, 2.94) | 1.27 (0.62, 2.60) | 1.14 (0.62, 2.08) |
| Caucasian | 4 | 1.09 (0.95, 1.26) | 1.26 (0.84, 1.91) | 1.06 (0.89, 1.25) | 1.08 (0.92, 1.26) | 1.26 (0.83, 1.89) |
| HWE | ||||||
| Yes | 5 | 1.14 (0.91, 1.44) | 1.39 (0.94, 2.05) | 1.08 (0.92, 1.27) | 1.15 (0.86, 1.52) | 1.31 (0.89, 1.92) |
| No | 2 | 1.13 (0.90, 1.42) | 1.16 (0.55, 2.45) | 1.58 (0.79, 3.19) | 1.43 (0.83, 2.44) | 0.95 (0.46, 1.97) |
His, histidine; Arg, arginine; OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium.