TABLE 3.
Feature combinations and correlation coefficients
| Features used | Variable type | Pathological + Clinical | Pathological + Clinical + MBD | Pathological + Clinical + LBD | Pathological + Clinical + MBD + Optical |
|---|---|---|---|---|---|
| Tumor size (cm) | Pathological | X | X | X | X |
| ER status (−/+) | X | X | X | X | |
| PR status (−/+) | X | X | X | X | |
| Combined Nottingham grade (1/2/3) | X | X | X | X | |
| Nuclear grade (1/2/3) | X | X | X | X | |
| Mitotic grade (1/2/3) | X | X | X | X | |
| Tubule formation grade (1/2/3) | X | X | X | X | |
| Age (avg. ± σ) | Clinical | X | X | X | X |
| BMI (avg. ± σ) | X | X | X | X | |
| Mammographic density (MBD) | Imaging | X | X | ||
| Local breast density (LBD) | X | X | |||
| Risk prediction accuracy (r) | 0.89 | 0.91 | 0.93 | 0.98 | |
| Area under the curve (AUC) | 0.86 | 0.88 | 0.92 | 0.97 |
Note: Risk prediction accuracy for different combinations of clinical, pathological and optical features.