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. 2021 Jul 26;3:704584. doi: 10.3389/fdgth.2021.704584

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Copyright © 2021 Curvello, Kast, Abuwarwar, Fletcher, Garnier and Loessner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of multicellular 3D cultures of tumour spheroids with stromal cells. The metabolic activity of MIA PaCa-2 (A) and PANC-1 (B) cell monocultures was initially lower than in the stromal and triple cultures in the collagen-nanocellulose matrices and increased over time. (C) Fewer spheroids were formed by MIA PaCa-2 cells in both 3D culture settings, while more spheroids were formed by PANC-1 cells. (D) The Young's moduli of the MIA PaCa-2 and PANC-1 triple cultures reached 3,303 ± 226 Pa and 2,233 ± 172 Pa, respectively. Results shown represent independent experiments performed in triplicates (n = 3, error bars = SD). Scale bar = 100 μm.