Table 1.

The different concepts from modern health care development that have been targeted to be met with the methodology presented in this paper. Their respective impact on informatics was determined by the authors for later inclusion in the construction of the present framework. References: Person-Centered Care (19), Interprofessional care (20), Value based healthcare (21). Shared decision making (2), Embedded trials (22).

Theoretical framework	Semantic needs
Patient-centered care	Transparent planning, Patient access to all information, Data obtained from the patient with annotation side by side in the medical record
Interprofessional care	Multi-tier care plan with transparent assignment of responsibilities, intuitive use of language
Value based health care	The ability to measure patient outcomes and PROMs across the full care cycle with fully planned terminology and procedures
Shared decision making	The ability to fully show detailed future alternatives for diagnosis and treatment and to involve the patient fully in all components of the decision making be it for big or small decisions.
Embedded clinical RWD generation	The generation of real-world data needs tools that generate fully semantically annotated but anonymous data