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. 2021 Oct 17;19:432. doi: 10.1186/s12967-021-03093-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — GLI2 is upregulated in gastric cancer and indicates a poor survival. a, b The mRNA and protein expression of GLI2 in six gastric cancer cell lines and GES-1. c, d GLI2 mRNA expression in GC in GEPIA and TCGA databases. e The relative GLI2 mRNA expression in 21 pairs of gastric cancer and adjacent normal tissues. f, g Protein expression and immunohistochemical staining of GLI2 in representative GC patients mentioned above. h, i Survival analysis based on K-M Plotter. (Scale bar = 100 μm, *p < 0.05, **p < 0.01, ***p < 0.001, ns = no significance)