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. 2021 Oct 17;19:432. doi: 10.1186/s12967-021-03093-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — MiR-144-3p downregulates GLI2 expression in gastric cancer. a The venn diagram of GLI2-targeted miRNAs predicted by bioinformatic analysis. b The heatmap was drawn to exhibit the decrease extent of GLI2 mRNA (red ≥ 25%, blue < 25%) in four gastric cancer lines after transfection with different kinds of miRNA mimics. c, d The protein expression of GLI2 in HGC-27 and BGC-823 after transfection with different kinds of miRNA mimics