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. 2020 Aug 11;2:14. doi: 10.3389/fdgth.2020.00014

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Copyright © 2020 Baker and Escott-Price.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of PRS using Different Methodologies; PRS(P+T), PRSice, PRS-CS and LDpred. The PRS is computed for all individuals in HipSci (19) open access data merged with the 1,000 Genomes data (18), scores are weighted using AD GWAS (5) summary statistics. Only SNPs with p ≤ 0.5 are included and the APOE region (chr19: 44.4-46.5Mb) is excluded for all methods.