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. 2021 Jul 8;3:660809. doi: 10.3389/fdgth.2021.660809

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Copyright © 2021 Das, Pearson, Taylor, Bouchet, Møller, Hall, Strivens, Tzeng and Gardner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotypic and clinical features that were most frequently reported (top 40) in 581 filtered disease signatures in Cohort 2 (subcohort of Cohort 1 with additional laboratory test results) associated with increased risk of hospitalization with severe COVID-19. Features associated with hypocalcemia (Calcium:0) and hypolipidemia (LDL:0, HDL:0) were reported in multiple disease signatures.