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. 2021 Oct 18;21:541. doi: 10.1186/s12935-021-02257-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — BMSC-derived exosomes can be taken up by OS cells. A Transmission electron micrograph of exosomes derived from BSMCs; B Nanoparticle tracking analysis of the diameter and concentration of exosomes; C Exosomal biomarkers protein were further examined by western blot; D Uptake of Dil-labelled exosomes by MG63 and 143B cells was detected; E, F The mRNA expression level of miR-769-5p (E) and DUSP16 (F) was detected by qRT-PCR in different groups; G The expression of DUSP16 protein was detected by western blotting in different groups. Data are presented as the means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001