Table 2.

Primary and secondary outcomes of DigiSep-trial

Outcomes	Data source	Timepoint/frame
Primary outcomes
DOOR/RADAR score	eCRF	28 days
Secondary outcomes
Long term mortality	Statutory health insurance data, eCRF	90, 180 days
Degree of organ dysfunction/failure: • Duration of mechanical ventilation • Length of time until shock resolution • Ongoing RRT-dependency	eCRF	28, 90, 180 days
Hospital length of stay	Statutory health insurance data, eCRF	28, 90, 180 days
Cumulative need for anti-infective drugs	Statutory health insurance data, eCRF	28, 90, 180 days
Beginning of a targeted anti-infective treatment regimen	eCRF	28 days
Resource utilization (outpatient and inpatient)	Statutory health insurance data	28, 90, 180 days
Duration and costs of incapacity to work	Statutory health insurance data	28, 90, 180 days
Direct medical costs (outpatient and inpatient)	Statutory health insurance data	28, 90, 180 days
Quality-of-life (QoL)	VR-36 questionnaire	0, 90, 180 days

Abbreviations: RRT renal replacement therapy; QoL quality of life; eCRF electronic case report from; DOOR/RADAR score Desirability of Outcome Ranking/Response Adjusted for Duration of Antibiotic Risk score