Table 2.

Outcome definition

Side event	Definition
Vascular disorders	(1) Vascular thrombosis including venous and arterial thrombosis; (2) vasculitis
Arhythmia	(1) PSVT; (2) VT; (3) atrial fibrillation; (4) ventricular fibrillation
Central nervous disorders	(1) dizzy; (2) headache
Diarrhoea	Noninfectious diarrhoea
Infection	(1) Noninjection site infection; (2) respiratory system infection; (3) urinary system infection; (4) biliary tract; (5) digestive tract and spontaneous peritonitis
Fever	Transient fever (low-grade, 37.3–38 °℃) within 48 h
Administration site conditions	(1) Injection site bleeding; (2) injection site swelling; (3) injection site pain; (4) injection site itchy; (5) injection site infection
Anaemia	Defined by Hb < 110 g/L
Metabolism and nutrition disorders	Mainly refer to malnutrition

PSVT paroxysmal supraventricular tachycardia, VT ventricular tachycardia