Table 3.
Study characteristics
| Author | Year | Study type | Location | Disease | Cell | Administration | Analysis | Study phrase | Language | Dose | Follow-up |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Emadedin | 2018 | RCT | Iran | Knee osteoarthritis | BMSC | Local implanation | PP | 1/2 | English | 40 × 106 cells | 6 months |
| Gao | 2013 | RCT | China | Acute myocardial infarction | BMSC | Intracoronary injection | PP | 3 | English | (3.08 ± 0.52) × 106 cells | 1 year |
| Gupta | 2013 | RCT | India | Critical limb ischemia | BMSC | Local injection | ITT | 1/2 | English | 2 × 106 cells/kg | 2 years |
| Lee | 2010 | RCT | South Korea | Ischemic stroke | BMSC | Intravenous injection | PP | 3 | English | 1 × 108 cells | 5 years |
| Zollino | 2018 | RCT | Italy | Chronic leg ulcers | BMSC | Local injection | PP | 2 | English | NA | 24 weeks |
| Weiss | 2013 | RCT | USA | COPD | BMSC | Intravenous injection | PP | 3 | English | 100 × 106 cells | 2 years |
| Xiao | 2017 | RCT | China | Dilated cardiomyopathy | BMSC | Intracoronary injection | PP | 3 | English | (4.9 ± 1.7) × 108 cells | 1 year |
| Hare | 2009 | RCT | USA | Acute myocardial infarction | BMSC | Intravenous injection | PP | 3 | English | 0.5, 1.6 and 5 × 106 cells/kg | 6 months |
| Huang | 2018 | RCT | China | Cerebral palsy | uc-MSC | Intravenous injection | PP | 3 | English | 5 × 107 cells | 2 years |
| Centeno | 2014 | RCT | USA | Knee osteoarthritis | BMSC | local implanation | PP | 3 | English |
75% BMSC, 12.5% PRP and 12.5% PBS |
2 years |
| FernaÂndez | 2018 | RCT | Spain | Multiple sclerosis | AD-MSC | Intravenous injection | ITT | 1/2 | English | 1 × 106 cells/kg, 4 × 106 cells/kg | 1 year |
| Vangsness | 2014 | RCT | USA | Partial medial meniscectomy | BMSC | Local implanation | PP | 3 | English | 50 × 106 cells | 2 years |
| Lin | 2017 | RCT | China | Liver failure | BMSC | Intravenous injection | PP | 3 | English | 1.0–10 × 105 cells/kg | 2 years |
| Molendijk | 2015 | RCT | USA | Crohn’s disease | BMSC | Local implanation | PP | 3 | English | 1–9 × 107 cells | 2 years |
| Tompkins | 2017 | RCT | USA | Aging frailty | BMSC | Intravenous injection | PP | 2 | English | 100–200 × 106 cells | 6 months |
| Li | 2013 | RCT | China | Leg ischemia | BMSC | Local implanation | PP | 3 | English | 1 × 107 cells/mL | 6 months |
| Lee | 2007 | RCT | South Korea | Multiple system atrophy | BMSC | Intravenous injection | PP | 3 | English | 4 × 107 cells | 1 year |
| Jaillard | 2020 | RCT | France | Ischemic stroke | BMSC | Intravenous injection | ITT | 3 | English | 100–300 × 106 cells | 2 year |
| Mathiasen | 2019 | RCT | Denmark | Ischaemic heart failure | BMSC | Intramyocardial injection | ITT | 3 | English | 0.2 mL | 1 year |
| Bartunek | 2016 | RCT | USA | Ischaemic heart failure | BMSC | Intramyocardial injection | ITT | 3 | English | 24 × 106 cells | 39 weeks |
| Bartunek | 2013 | RCT | Belgium | Heart failure | BMSC | Intramyocardial injection | PP | 3 | English | 600 -1200 × 106 cells | 2 years |
| Powell | 2012 | RCT | USA | Critical limb ischemia | BMSC | Local implantation | PP | 3 | English | 0.5 ml | 1 year |
| Olivera | 2017 | RCT | Brazil | Pulmonary emphysema | BMSC | Intravenous injection | ITT | 1 | English | 108 cells | 3 months |
| Sponer | 2018 | Prospective study | Czech | Femoral bone defects | BMSC | Local implantation | PP | 3 | English | (15 ± 4.5) × 106 cells | 1 year |
| Wang | 2016 | RCT | China | Knee osteoarthritis | uc-MSC | Local implantation | PP | 3 | Chinese | 2–3 × 107 cells | 6 months |
| Teraa | 2015 | RCT | The Netherlands | Limb ischemia | BMSC | Local implantation | ITT | 3 | English | 144–500 × 106 cells | 6 months |
| Bhansali | 2016 | RCT | USA | Diabetes mellitus | BMSC | Intravenous injection | PP | 3 | English | 1 × 106 cells /kg | 1 year |
| Panes | 2016 | RCT | Spain | Crohn’s disease | AD-MSC | Intralesional injection | ITT | 3 | English | 120 × 106 cells | 24 weeks |
| Averyanov | 2019 | RCT | Russia | Idiopathic pulmonary fibrosis | BMSC | Intravenous injection | PP | 3 | English | 2 × 108 cells | 1 year |
| Skyler | 2015 | RCT | USA | Type 2 diabetes | BMSC | Intravenous injection | ITT | 3 | English | 0.3–2 × 106 cells/kg | 1 year |
| Shi | 2010 | RCT | China | Chronic liver failure | BMSC | Intravenous injection | PP | 3 | English | 0.5 × 106 cells/kg | 72 weeks |
| Lublin | 2014 | RCT | USA | Multiple sclerosis | Placenta-Derived MSc | Intravenous injection | ITT | 3 | English | 600 × 106 cells | 1 year |
| Zhang | 2011 | RCT | China | Liver cirrhosis | uc-MSC | Intravenous injection | PP | 3 | English | 0.5 × 106 cells/kg | 1 year |
| Winkler | 2018 | RCT | Germany | Hip arthroplasty | Placenta-derived MSc | Local implantation | ITT | 3 | English | 1.5–3.0 × 108 cells | 2 years |
| Kim | 2018 | RCT | South Korea | Myocardial infarction | BMSC | Intracoronary injection | PP | 3 | English | (7.2 ± 0.90) × 107 cells | 1 year |
| Tan | 2012 | RCT | China | Kidney transplants | BMSC | Intravenous injection | PP | 3 | English | 1–2 × 106/kg | 1 year |
| Hauzeur | 2017 | RCT | Belgium | Osteonecrosis | BMSC | Local implantation | PP | 3 | English | 50 ml | 2 years |
| Noriega | 2017 | RCT | Spain | Intervertebral disc regeneration | BMSC | Local implantation | PP | 3 | English | 25 × 106 cells | 1 year |
| Gao | 2015 | RCT | China | Myocardial infarction | uc-MSC | Intracoronary injection | PP | 3 | English | 6 × 106 cells | 18 months |
| Ascheim | 2014 | RCT | USA | Left ventricular assist device patients | BMSC | Intramyocardial injection | PP | 3 | English | 25 × 106 cells | 1 year |
| Koh | 2012 | RCT | South Korea | Knee osteoarthritis | BMSC | Local implantation | PP | 3 | English | 1.89 × 106 cells | 1 year |
| Berry | 2019 | RCT | USA | Amyotrophic lateral sclerosis | BMSC | Local implantation | PP | 2 | English | 125 × 106 cells | 6 months |
| Chullikana | 2014 | RCT | India | Acute myocardial infarction | BMSC | Intracoronary injection | PP | 1/2 | English | 6.0 × 107 cells | 2 years |
| Oh | 2018 | RCT | Republic of Korea | Amyotrophic lateral sclerosis | BMSC | Intrathecal injections | ITT | 3 | English | 1 × 106 cells/kg | 6 months |
| Hess | 2017 | RCT | USA | Acute ischaemic stroke | BMSC | Intracerebral injection | ITT | 2 | English | 1200 × 106 cells | 3 months |
| Bartolucci | 2017 | RCT | Chile | Heart failure | uc-MSC | Intravenous injection | PP | 1/2 | English | 1 × 106 cells/kg | 1 year |
| Wang | 2017 | RCT | Australia | Anterior cruciate ligament reconstruction patients | BMSC | local implantation | ITT | 3 | English | 150 × 106 cells | 104 weeks |
| Wang | 2014 | RCT | China | Lyocardial infarction | BMSC | Intracoronary injection | PP | 3 | English | 1 × 108 cells/ml | 1 month |
| Gu | 2020 | RCT | China | Cerebral palsy | uc-MSC | Intravenous injection | PP | 3 | English | 4.5–5.5 × 107 cells | 1 year |
| Zhang | 2016 | RCT | China | Liver transplantation | uc-MSC | Intravenous infusion | PP | 3 | English | 1.0 × 106 cells/ kg | 2 years |
| Suk | 2016 | RCT | South Korea | Alcoholic cirrhosis | BMSC | Hepatic arterial injection | PP | 2 | English | 5 × 107 cells | 1 year |
| Zheng | 2014 | RCT | China | Acute respiratory distress syndrome | AD-MSC | Intravenous infusion | PP | 3 | English | 1 × 106 cells/kg | 4 weeks |
| Matas | 2019 | RCT | Chile | Knee Osteoarthritis | AD-MSC | Local implantation | PP | 1/2 | English | 2 × 107cells | 1 year |
| Wang | 2006 | RCT | China | Dilatedcardiomyopathy | BMSC | Intracoronary injection | ITT | 3 | Chinese | 8 × 107 cells | 6 months |
| Lin | 2012 | RCT | China | Liver fibrosis | uc-MSC | Intravenous infusion | ITT | 3 | Chinese | 0.5–1 × 106 cells/kg | 48 weeks |
| Xie | 2007 | RCT | China | Spinal cord injury | BMSC | Intrathecal injection | ITT | 3 | Chinese | 20.56–58.87 × 108 cells | 3 months |
| Xiao | 2012 | RCT | China | Myocardial infarction | BMSC | Intracoronary injection | ITT | 3 | Chinese | 1–10 × 109 cells | 3 months |
| Erpicum | 2018 | RCT | Belgium | Kidney transplantation | BMSC | Intravenous injection | PP | 1/2 | English | 2 × 106 cells/kg | 1 year |
| Shadmafar | 2017 | Prospective study | China | Liver fibrosis | uc-MSC | Hepatic artery injection | ITT | 3 | English | (42 ± 4) × 106 cells | 1 year |
| Zeng | 2015 | RCT | Iran | Rheumatoid arthritis | BMSC | Local implantation | PP | 1/2 | Chinese | 6.0–7.0 × 107 cells/kg | 52 weeks |
| Ning | 2008 | RCT | China | Hematologic malignancy | BMSC | Intravenous injection | NA | NA | English | 1.0–2.0 × 106 cells/kg | 3 years |
| José | 2020 | RCT | Spain | Knee osteoarthritis | BMSC | Local implantation | ITT | 2 | English | 100 × 106 cells | 1 year |
uc-MSC human umbilical cord mesenchymal stromal cell, BMSC bone marrow-derived human umbilical cord mesenchymal stromal cell, AD-MSC adipose-derived human umbilical cord mesenchymal stromal cell, PP per-protocol, ITT intention to treat, RCT randomized clinical trial, COPD chronic obstructive pulmonary disease