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. 2021 Oct 18;21:1113. doi: 10.1186/s12885-021-08861-x

Fig. 1.

Fig. 1

Overview of the EFFORT-MIBC study design. (1) Inclusion and exclusion criteria need to be fulfilled to be included in the study. (2) Stratification into treatment arms is based on the 18F-FDG-PET-CT result. In case of neo-adjuvant chemotherapy, stratification is based on the results of both 18F-FDG-PET-CT’s (e.g. prior to and after neo-adjuvant chemotherapy). Abbreviations: MIBC: muscle-invasive bladder cancer; CT: computed tomography; MRI: magnetic resonance imaging; 18F-FDG-PET-CT: 18F-fluorodeoxyglucose-positron emission tomography-computed tomography; MDT: metastasis-directed therapy