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. 2021 Oct 18;16:622. doi: 10.1186/s13018-021-02756-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Functional enrichment analyses of hub genes. A Top 20 GO functional enrichment of hub genes. B KEGG pathways of hub genes. C Top 10 Reactome pathway of hub genes. The bubble pattern shows the top 10 enrichment pathways with Entities ratio, Entities found (count) and Entities FDR. Y-axis represents pathway name and X-axis represents rich factor. Size and color of each bubble represent the number of differentially expressed genes enriched in the pathway and − log10 (q-value), respectively. D Top 10 Reactome events hierarchy. The bar chart demonstrates that the gene sets involved in metabolism of proteins and signal transduction were significantly enriched in pathways related to SNI status