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. 2021 Oct 17;21:538. doi: 10.1186/s12935-021-02228-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Suppression of AhR signals improved the anticancer effects of chemotherapy. A The tumor volume of SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. B Survival analysis of SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. C The tumor volume of SMC-7721 bearing mice treated with PBS, PDM2, 5-FU and PDM2 combining 5-FU. D Survival analysis of SMC-7721 bearing mice treated with PBS, PDM2, 5-FU and PDM2 combining 5-FU. E, Expression of IL-6, AhR, p-STAT3, total STAT3 and NF-kB in Vector (Vec) or TDO2 overexpression (OE) SMC-7721 tumor tissues using Elisa or western blotting analysis. F The tumor volume of TDO2 overexpression SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. G, Survival analysis of TDO2 overexpression SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. *p < 0.05, **p < 0.01