Table 1.
Incidence of suicide among AYA cancer patients by demographic and tumor characteristics
| Characteristic | Patients with cancer | Suicide | Suicide per 100,000 Person-years a |
SMR ab | 95% CI | ||
|---|---|---|---|---|---|---|---|
| No | % | No | % | ||||
| Sex | |||||||
| Male | 223,123 | 38.97% | 658 | 67.07% | 33.75 | 1.484 | 1.374–1.601 |
| Female | 349,377 | 61.03% | 323 | 32.93% | 9.01 | 1.449 | 1.299–1.616 |
| Race | |||||||
| White | 455,982 | 79.65% | 901 | 91.85% | 19.55 | 1.27 | 1.189–1.355 |
| Black | 58,305 | 10.18% | 34 | 3.47% | 7.46 | 0.78 | 0.558–1.092 |
| Other | 58,213 | 10.17% | 46 | 4.69% | 9.83 | 1.039 | 0.778–1.387 |
| Material status | |||||||
| Married | 259,679 | 45.36% | 376 | 38.33% | 13.13 | 0.908 | 0.821–1.005 |
| Unmarried | 263,589 | 46.04% | 519 | 52.91% | 24.09 | 1.644 | 1.508–1.792 |
| Unkmon | 49,232 | 8.60% | 86 | 8.77% | 18.72 | 1.312 | 1.062–1.621 |
| Stage at presentation | |||||||
| In situ | 43,246 | 7.55% | 66 | 6.73% | 13.48 | 0.927 | 0.728–1.180 |
| Localized | 214,419 | 37.45% | 386 | 39.35% | 14.76 | 1.019 | 0.922–1.126 |
| Regional | 99,829 | 17.44% | 142 | 14.48% | 15.23 | 1.06 | 0.899–1.249 |
| Distant | 65,836 | 11.50% | 66 | 6.73% | 20.87 | 1.444 | 1.134–1.838 |
| Unstaged/Unknown | 149,170 | 26.06% | 321 | 32.72% | 29.28 | 1.94 | 1.739–2.164 |
| No of primary | |||||||
| Single | 475,758 | 83.10% | 852 | 86.85% | 19.07 | 1.332 | 1.246–1.425 |
| Multiple | 96,742 | 16.90% | 129 | 13.15% | 11.67 | 0.828 | 0.697–0.984 |
| Year of diagnosis | |||||||
| 1973–1983 | 50,407 | 8.80% | 182 | 18.55% | 16.64 | 1.176 | 1.017–1.360 |
| 1984–1994 | 89,064 | 15.56% | 322 | 32.82% | 22.28 | 1.552 | 1.391–1.731 |
| 1995–2005 | 184,245 | 32.18% | 314 | 32.01% | 15.63 | 1.085 | 0.971–1.211 |
| 2006–2015 | 248,784 | 43.46% | 163 | 16.62% | 16.27 | 1.136 | 0.975–1.325 |
| All AYA patients with cancer | 572,500 | 1 | 981 | 1 | 17.68 | 1.234 | 1.159–1.313 |
SEER Surveillance, epidemiology, and end results, SMR standardized mortality ratio
aAdjusted to the age distribution in the population served by the SEER program.
bFor the categories of sex and race, SMR reference population was the specific category in the general US subpopulation (eg, the SMR for male AYAs is the observed number of suicides in male AYA patients divided by the expected number of suicides based on the rate in men in the general AYA population). For marital status, stage at presentation, number of primary tumors, and year of diagnosis, SMR reference population is the entire general US AYA population from 1969 through 2015.