Table 2.
Suicide rates by anatomic site of cancer
| Sitea | No of suicides | No of patients | Survival time (person-yeats) | Overall(male and female) | Male AYA patientse | Female AYA patientse | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Suicide ratebc | SMRcd | CIcd | Suicide ratebc | SMRcd | CIcd | Suicide ratebc | SMRcd | CIcd | ||||
| Lung and bronchus | 9 | 8029 | 34,610.2 | 22.79 | 1.90 | 0.986–3.651 | 35.28 | 1.69 | 0.759–3.762 | 15.34 | 2.53 | 0.815–7.835 |
| Stomach | 5 | 4294 | 12,559.5 | 37.12 | 2.97 | 1.234–7.124 | 65.01 | 2.28 | 0.736–7.079 | 20.5 | 5.38 | 1.344–21.495 |
| Oral cavity and pharynx | 25 | 7020 | 74,198.6 | 29.23 | 2.28 | 1.538–3.369 | 51.39 | 2.25 | 1.452–3.489 | 16.02 | 2.39 | 0.993–5.730 |
| Hodgkin lymphoma | 66 | 25,924 | 300,315.1 | 17.33 | 1.56 | 1.223–1.981 | 34.17 | 1.58 | 1.216–2.063 | 7.29 | 1.43 | 0.794–2.587 |
| Kidney | 9 | 8327 | 62,117.5 | 23.76 | 0.93 | 0.483–1.784 | 49.21 | 0.88 | 0.418–1.840 | 8.59 | 1.17 | 0.292–4.663 |
| Thyroid | 45 | 52,147 | 548,098.5 | 11.04 | 0.89 | 0.666–1.194 | 21.14 | 1.00 | 0.662–1.499 | 5.02 | 0.80 | 0.529–1.220 |
| Nervous system | 42 | 19,736 | 142,982.9 | 30 | 2.04 | 1.510–2.764 | 46.93 | 1.90 | 1.345–2.690 | 19.91 | 2.68 | 1.440–4.975 |
| Non-hodgkin lymphoma | 53 | 27,002 | 206,747.1 | 19.6 | 1.66 | 1.267–2.171 | 38.21 | 1.71 | 1.280–2.282 | 8.51 | 1.39 | 0.663–2.916 |
| Leukemias | 19 | 20,857 | 117,841.5 | 15.76 | 1.11 | 0.707–1.739 | 21.17 | 0.83 | 0.472–1.465 | 12.54 | 2.59 | 1.235–5.432 |
| Colorectal | 40 | 20,568 | 143,728.9 | 28.26 | 1.95 | 1.427–2.652 | 44.23 | 1.87 | 1.309–2.677 | 18.73 | 2.21 | 1.187–4.101 |
| Bladder | 17 | 4433 | 64,280.5 | 17.56 | 1.41 | 0.875–2.263 | 28.31 | 1.37 | 0.823–2.266 | 11.15 | 1.81 | 0.454–7.254 |
| Nasopharyngeal carcinoma | 6 | 1747 | 14,923.8 | 33.51 | 3.14 | 1.410–6.987 | 89.73 | 3.63 | 1.628–8.069 | 0 | 0.00 | — |
| Gonad | 9 | 6501 | 68,776.8 | 39 | 1.94 | 1.009–3.726 | 87.33 | 5.04 | 1.261–20.167 | 10.2 | 1.65 | 0.786–3.459 |
| Breast | 53 | 58,699 | 547,036.5 | 8.81 | 1.45 | 1.104–1.891 | ||||||
| Cervix and uterus | 43 | 29,976 | 341,688.2 | 12.02 | 1.95 | 1.447–2.630 | ||||||
| Naso cav,mid ear,sinus,larynx | 9 | 1417 | 13,479 | 55.91 | 4.00 | 2.083–7.692 | 54.62 | 3.11 | 1.395–6.912 | 56.68 | 9.49 | 3.060–29.410 |
| Osseous and chondrommatous | 17 | 6359 | 53,608 | 33.16 | 2.33 | 1.446–3.743 | 41.32 | 1.95 | 1.109–3.440 | 28.3 | 4.30 | 1.788–10.322 |
| Soft tissue | 87 | 26,070 | 188,201.8 | 34.2 | 3.06 | 2.479–3.773 | 72.81 | 3.24 | 2.595–4.044 | 11.18 | 2.06 | 1.072–3.959 |
| Germ cell and trophoblastic | 128 | 39,712 | 454,603 | 15.08 | 1.32 | 1.109–1.568 | 28.74 | 1.31 | 1.097–1.560 | 6.93 | 1.78 | 0.668–4.741 |
| Melanoma and skin carcinomas | 91 | 45,699 | 539,030.5 | 15.03 | 1.28 | 1.040–1.569 | 27.39 | 1.27 | 0.989–1.621 | 7.67 | 1.30 | 0.900–1.888 |
| All AYA patients with single primary tumor | 852 | 475,758 | 4,473,748.2 | 19.04 | 1.55 | 1.447–1.655 | 34.47 | 1.54 | 1.417–1.669 | 9.85 | 1.57 | 1.393–1.763 |
| General US AYA population | 12.31 | 1.00 | Reference | 22.42 | 1.00 | Reference | 6.28 | 1.00 | Reference | |||
SMR standardized mortality ratio
aAnalysis was limited to tumor sites for which at least 100,000 person years were accrued
bPer 100,000 person-years
cAdjusted to the age, race, and sex distributions of patients with a single primary tumor
dReference population: general US AYA population, 1969 to 2015
eSex-specific analysis, adjusted for age and race distributions of patients with single primary tumor