Table 2.

Geometric mean ratios (GMR) and percent difference (%Diff) in cytokine/chemokine concentrations (A) per 10 packyears of smoking; (B) for current/recent^a vs. past/never smokers, among sample of women in the NHS/NHSII cohorts (N=1177).

A.Packyears/10
		Model 1b				Model 2c
Biomarker	GMR	SE	%Diff	p	GMR	SE	%Diff	p
BLySd	1.01	1.01	1.4	0.04	1.02	1.01	1.7	0.02
IL-10e	0.83	1.06	−16.6	<0.001	0.83	1.06	−16.6	0.001
IP-10e	0.98	1.03	−2.2	0.52	0.97	1.03	−3.4	0.30
SCFd	0.99	1.01	−0.9	0.14	0.99	1.01	−0.6	0.33

B. Current or recent smokers vs. past or never smokers
		Model 1b				Model 2c
Biomarker	GMR	SE	%Diff	p	GMR	SE	%Diff	p
BLySd	1.09	1.03	8.7	<0.01	1.10	1.03	9.5	<0.001
IL-10e	0.54	1.24	−46.2	<0.01	0.55	1.24	−44.9	<0.01
IP-10e	1.07	1.14	7.0	0.60	1.04	1.14	4.1	0.76
SCFd	0.97	1.02	−3.3	0.15	0.98	1.02	−2.0	0.38

^aCurrent/recent smoker: current or in past 4 years, vs quit more than 4 years ago or never smoked. Separate models were run for each biomarker outcome.

^bModel 1 adjusted for age/5yrs (continuous); black race (white, other is ref); census tract-based household income (continuous); cohort (N1 or N2).

^cModel 2 additionally adjusted for steroid use at time of blood draw; ever used oral contraceptives (OC); menopause hormone status: (1) pre (ref) (2) post never; (3) post past use; (4) post current; BMI (continuous); alcohol use: (1) never (ref); (2) >0 - <5g/day; (3) ≥5g/day.

^dModels run using linear regression.

^eModels run using tobit regression to account for proportion of data below the limit of detection of the assay.