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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Arthritis Care Res (Hoboken). 2021 Sep 24;73(11):1583–1589. doi: 10.1002/acr.24370

Table 3.

Geometric mean ratios (GMR) and percent difference (%Diff) in cytokine/chemokine concentration (A) per 10 packyears of smoking; (B) for current/recenta vs. past/never smokers; stratified by ANA/ENA status at blood drawa, among sample of women in the NHS/NHSII cohort (N=1177).

A.Packyears/10
Fully Adjusted Modelb
Biomarker ANA/ENA levela GMR SE %Diff p p(int)*
BLySc ANA/ENA− 1.01 1.01 1.0 0.21 0.02
ANA/ENA+ 1.05 1.02 5.2 <0.01
IL-10d ANA/ENA− 0.84 1.06 −15.6 <0.01 0.98
ANA/ENA+ 0.79 1.15 −20.7 0.09
IP-10d ANA/ENA− 0.97 1.04 −3.1 0.43 0.95
ANA/ENA+ 0.95 1.07 −4.9 0.49
SCFc ANA/ENA− 0.99 1.01 −0.6 0.36 0.80
ANA/ENA+ 1.00 1.01 −1.0 0.86
B. Current or recent smokers vs. past or never smokerse
Fully Adjusted Modelb
Biomarker ANA/ENA levela GMR SE %Diff p p(int)*
BLySc ANA/ENA− 1.05 1.03 4.7 0.13 <0.01
ANA/ENA+ 1.24 1.06 24.2 <0.0001
IL-10d ANA/ENA− 0.60 1.27 −40.0 0.03 0.68
ANA/ENA+ 0.39 1.58 −60.5 0.04
IP-10d ANA/ENA− 1.12 1.17 11.5 0.48 0.49
ANA/ENA+ 0.86 1.27 −14.2 0.52
SCFb ANA/ENA− 0.97 1.03 −2.9 0.28 0.59
ANA/ENA+ 1.01 1.04 0.8 0.85
a

ANA/ENA−, n=882; ANA/ENA+, n=295.

b

Adjusted for age/5yrs (continuous); black race (white, other is ref); census tract-based household income (continuous); cohort (N1 or N2); steroid use at time of blood draw; ever used oral contraceptives (OC); menopause hormone status: (1) pre (ref) (2) post never; (3) post past use; (4) post current; BMI (continuous); alcohol use: (1) never (ref); (2) >0 - <5g/day; (3) ≥5g/day.

c

Model run using linear regression.

d

Model run using tobit regression.

e

Current/recent smoker: current or in past 4 years, vs quit more than 4 years ago or never smoked.

*

P for interaction of smoking*ANA/ENA status.