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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Toxicol In Vitro. 2021 Jun 30;76:105208. doi: 10.1016/j.tiv.2021.105208

Figure 1.

Figure 1.

Screening study of antioxidants at in vivo concentrations (control = no antioxidant, L-tyrosine at 78 μM, uric acid at 43 μM, ascorbic acid at 530 μM, L-cysteine at 14.3 μM, and glutathione at 5.5 μM). Three representative chemicals, (A) cyclohexanol GHS category 1; (B) 2,4-pentanediol GHS NC; and (C) triethylene glycol GHS NC, were used to screen the effects of each antioxidant. Dashed lines show the NC and category 1 cut-offs for the OptiSafe prediction model.