. Author manuscript; available in PMC: 2022 Oct 1.

Published in final edited form as: Toxicol In Vitro. 2021 Jun 30;76:105208. doi: 10.1016/j.tiv.2021.105208

Table 3.

OptiSafe and OS2 Score Comparison

Chemical Name	GHS	Condition	OptiSafe Score, AVG ± STD	OS2 Score, AVG ± STD
Cyclohexanol (108-93-0)	Cat. 1	Pos.	52.6 ± 1.1	66.9 ± 4.9
2,4-Pentanediol (625-69-4)	NC	Neg.	12.0 ± 1.4	10.2 ± 0.7
Dodecane (112-40-3)	NC	Neg.	0.9 ± 0.8	3.0 ± 2.6
Triphenyl phosphite (101-02-0)	NC	NOTROS/CL	113.3 ± 2.1	169.0 ± 9.9
Ethyl acetate (141-78-6)	NC	NOT ROS/CL	23.9 ± 2.0	25.6 ± 2.4
2,4-Pentanedione (123-54-6)	NC	NOT ROS/CL	45.3 ± 1.4	42.3 ± 6.6
2,2-Dimethyl-3-pentanol (3970-62-5)	NC	NOT ROS/CL	19.2 ± 1.2	15.1 ± 0.4

OptiSafe (without antioxidants), OS2 = OptiSafe2 (OptiSafe with antioxidants added); GHS = Globally Harmonized System of classification and labelling of chemicals; Cat. = Category; NC = Not classified; Pos. = Positive control; Neg. = Negative control; AO = Antioxidant; ROS = Reactive oxygen species; CL = Crosslinker; AVG = Average; STD = Standard deviation.